What are SARMS?
Selective Androgen Receptor Modulators (SARMs)
Selective androgen receptor modulators (SARMs) should ONLY be used by men and women over 21 years old. SARMs are NOT meant for children, teenagers, and pregnant or nursing women.
SARMs may be banned by certain organizations so it’s your responsibility to perform due-diligence and ensure compliance. Consult your healthcare professional before using SARMs, especially if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low “good” cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not exceed the recommended serving and use SARMs at your own risk. This article and SARMs, are not intended to diagnose, treat, cure, or prevent any disease.
Introduction to SARMs
Selective androgen receptor modulators, also known as SARMs, are marketed as having similar positive effects on muscle and strength that pro-hormones and anabolic androgenic steroids (AAS) offer, but with fewer side effects. Essentially, SARMs are compounds that can block or stimulate key receptors in body tissue, which can help to increase the positive effects and decrease the unwanted side effects based on the compound’s mechanism(s) of action.
SARMs have been shown to increase muscle mass, bone mass, and fat loss without significant increases in estrogen or shutting down the Hypothalamic-pituitary-gonadal axis (HPG axis). As defined by Negro-Vilar, an ideal anabolic SARM is “orally active agent with once daily dosing and anabolic effects on muscle and bone, but no or lesser activity in the prostate.”
In this article we will examine the history, mechanisms of action, benefits, and side effects of SARMs, popular SARMs, and SARM-like products. At the end of this article you should have a much better understanding of SARMs and be able to make a more informed decision as to whether SARMs are right for you.
Properties common to all SARMs
There are certain properties that are generally common to all SARMs. Some of these properties can be listed as follows:
– Muscle wasting prevention
– Lean muscle gains
– Cutting body fat
– Improving the health of joints and soft tissues
– Overall performance enhancing
Types of SARMs
In spite of the fact that all SARMs have medical benefits and several common traits, some are more favourable for certain purposes, whilst others stack particularly well to get a certain synergy. The following are the most popular SARMs and their primary properties:
Cardarine (GW) is a PPAR (peroxisome proliferator-activated receptors) that is sold as a SARM because it is popularly ran alone or stacked with other SARMs in order to provide endurance benefits and fat loss. It has no hormonal effects, so there is zero suppression.
Andarine (S4) is a SARM with some great possibilities at adding strength. Moreover, it stacks very well to help burn fat and add lean muscle mass. Unlike cardarine, there is some suppression, and even though there is far less suppression than with anabolic steroids, a post cycle therapy (PCT) is needed.
Ostarine (MK) is a SARM with pronounced healing abilities, and it stacks well to help add lean muscle mass and burn fat. Since it is minimally suppressive when used for less than 4 weeks at a conservative dosage, ostarine can be used in PCT.
Ligandrol (LGD) is the most powerful SARM in its class. Thus, it is popularly used to add mass and strength quickly on solo cycle, or as part of a stack. However, there is some suppression, so a PCT is needed.
Ibutamoren (MK677) is a growth hormone secretagogue that can be run solo or stacked with other SARMs. It has many healing benefits. Moreover, will help burn fat and add muscle mass. It doesn’t shut you down, since you’re not providing exogenous GH. MK works by stimulating YOUR OWN GH production.
YK11 shows a lot of promise as an apt anabolic SARM. With the muscle growth potential it brings, it’s as effective as anabolic steroids and prohormones without the unwanted side effects connected to the latter. YK-11 is a powerful SARM supplement promoting massive lean muscle gains which is a great benefit for those wanting to have an aesthetic and shredded physique!
SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits. “….decreased lipogenesis and cholesterol/bile acid synthesis in the liver, increased lipid and glucose oxidation in the skeletal muscle, and decreased triglyceride synthesis and storage in the WAT.” This means that less fat is stored, less cholesterol is developed by the liver, and more fat and glucose is burned in the muscles.
SARMs and Suppression
Suppression takes place when your pituitary glands do not produce as much Luteinizing hormone (LH) – the hormone responsible for testosterone production by the testes. In fact, the suppression caused by anabolic steroids is so severe that your pituitary glands will cease producing almost any LH at all. On the other hand, SARMs will not affect LH levels.
Although SARMs can be somewhat suppressive, they are not even nearly as suppressive as anabolic steroids are. Certain SARMs (like ostarine) will drop LH by only 10-20%, compared to 95% seen with anabolic steroids. Hence, as mentioned before, it can be used in PCT. Meanwhile, such SARMs as LGD and S4 should not be used in PCT, but rather must be followed by a PCT.
Post cycle therapy is needed to help preserve muscle gains, keep fat away, retain strength, and maintain mood strong. Furthermore, PCT is also important when it comes to cleansing organs and providing the body with vitamins/minerals to keep it strong.
However, many athletes make the mistake of failing to run a proper PCT, which makes them quit working out during this time due to a considerably decreased motivation. Therefore, a good PCT helps you get through the period where your HPTA recovers and you start producing testosterone on your own.
Content Credit: iSarms.com